Platelet Rich Fibrin (PRF)

What is PRF?

Platelet rich fibrin (PRF) is an autologous source of growth factors that can be added to surgical sites to promote wound healing. Proper protocols utilizing PRF are typically achieved using high g-forces to selectively layer blood cells based on density, without the use of anti-coagulants. The resulting fibrin network provides a 3-dimensional provisional matrix that contains a high concentration of human growth factors.

In dentistry, PRF has been utilized for the treatment of extraction sockets, soft tissue management, gingival recessions, bone grafts, sinus lifts, and regeneration of periodontal defects. A blood draw is started and the liquid is centrifuged to selectively separate blood cells. Once separated, the induvial layers are comprised of a fibrin clot rich in platelets, trapped between an acellular plasma layer and erythrocytes (or red blood cells). The clot can then be removed and added to bone grafts or the surgical site. When PRF dissolves, the solid fibrin matrix slowly remodels, similar to a natural blood clot. Platelets and cytokines are retained and released gradually over time.

Advantages of PRF are that fibrin organizes the slow release of growth factors over multiple days and the growth factors are entirely derived from autogenous (or self) sources.